ESR10 Characterise the formation and involvement of lipids from lipoxygenases (LOX) in RA using animal models and human tissues (Cardiff University)
We seek a highly motivated PhD-student who will apply lipidomic methods to human RA cohorts and animal models, to determine the role of lipids from lipoxygenases (LOX) in the pathogenesis of this disease. LOXs generate a complex array of bioactive lipids, and are strongly implicated in RA development. Here we will focus on how LOX drives systemic complications of RA through generating lipids that move through the bloodstream to promote blood clotting and thrombotic complications.
The PhD-student will plan and undertake the experiments, and will report and publish the results in scientific journals and at international conferences. The project includes fundamental structural molecular and cellular work as well as translational applications. Full training in animal models, cohort sample analysis and lipidomics MS/MS will be provided
The Systems Immunity Research Institute draws on the wealth of world-leading expertise in infection, immunity and big data across the College of Biomedical & Life Sciences and the College of Physical Sciences & Engineering at Cardiff University. We explore highly complex immune responses in an integrated manner, using experimental, clinical and systems-based approaches. Our research uses state-of the art technologies and benefits from unique access to disease models, patient cohorts and tissue banks. We answer fundamental questions concerning the mechanisms of immunity and develop diagnostic and targeted treatment strategies for real-world applications. The Cardiff Lipidomic group specialises in the discovery and characterisation of lipids that drive inflammation and blood clotting. The administrative hub of LIPID MAPS (www.lipidmaps.org) is hosted locally.
You have a Masters or BSc (2.1 or above) degree in biomedical sciences or chemistry, preferably with an interest or expertise in analytical chemistry. For biomedical applicants, experiences with cell biology and mouse models would be helpful. We are seeking a highly motivated researcher keen to work in an interdisciplinary team. English language skills are essential for communication within the team and the consortium, but also for scientific presentations and publications. PhD-students involved in this project will make short-term exchange visits with the institutes of the other partners. Training in big data and informatics including programming will be provided as part of our PhD training in Systems Immunity.
You will be employed on the basis of a full time employee (35 hrs per week) for a maximum of 3 years and the PhD-traject will be completed with a doctoral thesis. Your salary is around £37258 per year, however actual salaries will be dependent on the individual personal circumstances.
Please provide a full application in English including a CV, a brief statement of research experiences, and contact details of two referees. You will be asked to give a presentation as part of the selection procedure.