ESR11 Pharmametabolic study of OA and RA using MS and NMR spectroscopy (PG)
We seek a highly motivated PhD-student who will apply metabolomic methods to human rheumatoid Arthritis cohorts and animal models, to define molecular diagnostic markers associated to therapy response, as well as therapy related side effects. The PhD-student will plan and undertake the experiments, and will report and publish the results in scientific journals and at international conferences. The student will also perform metabolites analysis in specific in vitro cell culture experiments, aiming to address resolution mechanisms (in close collaboration with Leiden University Medical Center (LUMC), Leiden, The Netherlands and Eberhard Karls University Tübingen (EKU), Germany. Analysis of biologically relevant sample materials will allow the student to acquire a solid knowledge in NMR and MS based metabolomics analytical chemistry, biochemistry and biology with a special focus on arthritis,
The Company and the University
PharmaGnose S.A. is a spin off company of the University of Athens supplier of R&D solutions in terms of products and services (http://pharmagnose.com/). PharmaGnose is service provider for development and validation of analytical methods using state of the art analytical techniques, profiling and fingerprinting, pharmacokinetic studies, LCMS and NMR based metabolomics in human biofluids and plant extracts supervised by Prof E, Mikros (http://biospec.pharm.uoa.gr/). The student will be enrolled in the School of Medicine National Kapodistrian University of Athens and collaborate for sample collection with the Department of Pathophysiology fully equipped with cell culture, molecular biology, histology, flow cytometry and autoantibodies analysis facilities, and of a 45-bed clinic as well as daily and outpatient clinics, under the guidance of professor A. Tzioufas.
We are seeking a highly motivated researcher with an MSc degree in biomedical sciences or chemistry, preferably with expertise in analytical chemistry. Applicants experienced in NMR and/or MS will be prioritized. Experience with cell biology would be helpful. English language skills are essential for communication within the team and the consortium, but also for scientific presentations and publications. PhD-students involved in this project will make short-term exchange visits in LUMC and EKU. Training in multivariate statistics will be provided as part of our PhD training.
What we offer
You will be employed on the basis of a 40-hour week. Appointment is for a maximum of four years, to be completed with a doctoral thesis. Your salary is around € 34,000 per year.
Please provide a full application in English including a CV, a brief statement of research experiences, and contact details of two referees. You will be asked to give a presentation as part of the selection procedure.