Not available anymore - ESR3 Determining the effect of pro-resolving lipids on immunometabolism and immune polarization of myeloid cells in the context of rheumatic diseases (LUMC)
We are looking for a PhD-student who will work on project that focuses on the identification of known and novel lipids that functionally modulate the metabolic and immune polarizing properties of myeloid cells that lead to dampening of inflammatory immune responses associated with rheumatic diseases. The PhD-student is responsible for planning and performing the experiments and reporting and publishing the results in scientific journals and at international conferences. The project comprises of fundamental molecular and cellular work as well as more translational research with a special focus on arthritis, and involves classical immunological assays as well as metabolomics.
At the Leiden University Medical Centre (LUMC), we are continually seeking to improve the quality of healthcare. You will work primarily within the Leiden Immunoparasitology Group (LIPG), which is part of the department of Parasitology. While a main research line of the department is centred around understanding the immunological basis of host parasite interactions, a new research line within the department focuses on cellular immunemetabolism of myeloid cells. In addition, given the multidisciplinary nature of this project, you will perform this research in close collaboration with other departments, in particular the Center for Proteomics and Metabolomics (CPM) and Rheumatology. This ensures that this research will be performed in a very stimulating and diverse environment with an excellent embedding of the project within the LUMC. Finally, part of the training period will be carried out at the University of Glasgow, Queen Mary University of London and Beckman and Coulter Life Sciences (France).
You have a Master degree in biomedical sciences, preferably with experience in cellular immunology and/or metabolism. Practical experience with cell culture and mice would be an asset. Additional experiences with molecular cell biology tools (Western Blot and qPCR or metabolomics) will be considered an advantage. You are a highly motivated independent team player with a flexible work approach and the ability to work effectively within a multidisciplinary team. English language skills are essential for communication within the team and the consortium, but also for scientific presentations and publications. PhD-students involved in this project will make short-term exchange visits with the institutes of the other partners.
You will be employed on the basis of a 36-hour week. Appointment is for a maximum of four years, to be completed with a doctoral thesis. Your salary is € 2.422 gross per month in the first year, amounting to € 3.103 in the fourth year (scale PhD students, CAO-UMC).
LUMC can offer you highly favourable terms and conditions of employment. For example, you will receive an 8% holiday remuneration and a year-end bonus. In addition, you will have the opportunity to join the collective health insurance scheme for University Hospitals. LUMC offers excellent facilities for education and training, child-care centres, and career advice. In addition, you will benefit from various leave arrangements and other extras. You can read more about these facilities elsewhere on this site.
Please provide a full application in English including a CV, a brief statement of research experiences, and contact details of two referees. You will be asked to give a presentation as part of the selection procedure.