After obtaining his Master’s Degree in 2005 at the University of Amsterdam, specializing on host-pathogen interactions, Bart started his PhD at the department of Parasitology at the Leiden University Medical Center (LUMC) in the group of Prof. Dr. Maria Yazdanbakhsh.
During his PhD he studied the immunomodulatory effects of parasitic worm, Schistosoma, on dendritic cells (DCs). Following his PhD In 2010, he started as a postdoctoral fellow, to work in the emerging field of immunometabolism of DCs, macrophages and T cells, in the group of Prof. Dr. E.J. Pearce at the School of Medicine of Washington University, St Louis, Missouri, USA. Through support from a VENI fellowship from NWO, and a Marie Curie Career Integration Grant, he returned to the department of Parasitology at the LUMC in 2014, where he is now an assistant professor.
Bart is an editorial board member of European Journal of Immunology and is a recipient of an LUMC Fellowship and VIDI grant from NWO. His group currently consists of 6 members and his main interest lies in understanding the metabolic underpinnings of the immunoregulatory functions of DCs and macrophages, with the ultimate goal to identify metabolic pathways that can be targeted to manipulate the functional properties of myeloid cells for therapeutic purposes. Bart will be supervising one ESR within this consortium.
Recent key research papers:
- Pelgrom LR, Patente TA, Sergushichev A, Esaulova E, Otto F, Ozir-Fazalalikhan A, van der Zande HJP, van der Ham AJ, van der Stel S, Artyomov MN, Everts B. LKB1 expressed in dendritic cells governs the development and expansion of thymus-derived regulatory T cells. Cell Res, 2019, May;29(5):406-419
- Patente TA, Pelgrom LR, Everts B. Dendritic cells are what they eat: how their metabolism shapes T helper cell polarization. Curr Opin Immunol. 2019 Mar 12;58:16-23
- Hansen IS, Krabbendam L, Bernink JH, Loayza-Puch F, Hoepel W, van Burgsteden JA, Kuijper EC, Buskens CJ, Bemelman WA, Zaat SAJ, Agami R, Vidarsson G, van den Brink GR, de Jong EC, Wildenberg ME, Baeten DLP, Everts B, den Dunnen J. FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming. Nat Commun. 2018 Feb 28;9(1):863
- Kaisar MMM, Ritter M, Del Fresno C, Jónasdóttir HS, van der Ham AJ, Pelgrom LR, Schramm G, Layland LE, Sancho D, Prazeres da Costa C, Giera M, Yazdanbakhsh M, Everts B. Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses. PLoS Biol. 2018 Apr 18;16(4):