Work Packages in ArthritisHeal Project
The ArthritisHeal training network consists of four scientific WPs corresponding with the scientific objectives 1-4. Each of the 12 ESR projects will be positioned in one or more of WPs 1-4 having intense interaction according to the central interdisciplinary and translational training idea of ArthritisHeal. The common basis for all WPs is the epidemiologic and mechanistic evaluation of pro-resolving lipid pathways and functions in rheumatic diseases.
The interconnection of the WPs can be described as follows:
Known (e.g. from other inflammatory diseases) and novel pro-resolving lipids will be investigated in human patient cohorts at various stages of disease in WP1. Novel pro-resolving lipids will be fed into this WP from WP2, which is dedicated to discovery of novel pro-resolving mediators using untargeted lipidomics in animal models. The mechanism of action of the targets resulting from both these WPs will be evaluated in animal models of disease (WP3), whereas WP4 will assess the biological relevance of these pathways in human cells and tissues to investigate cellular and molecular mechanisms. This will add a deeper layer of translational research to the project.
Since the central idea of the ArthritisHeal project is the translational and multi-disciplinary training of ESRs, WP5 will be exclusively dedicated to training whereas WP6 will address dissemination and outreach of the project. Finally, WP7 will be fully dedicated to the management of the ArthritisHeal consortium.